With schools re-opening, Yonker et al. sought to evaluate the clinical and biochemical characteristics of COVID-19 in children aged 0-22 years, with confirmed SARS-CoV-2 or multisystem inflammatory syndrome (MIS-C). Out of 192 children, 26% (49/192) had SARS-CoV-2 and 9% (18/192) had MIS-C. Clinically, children with SARS-CoV-2 mostly presented with non-specific infection symptoms and about half had confirmed fever (51%). Biochemically, pediatric nasopharyngeal viral load was significantly greater within the first two days of symptoms compared with that of SARS-CoV-2-confirmed adults. IgM and IgG bound to SARS-CoV-2 spike protein were increased in severe MIS-C patients. Overall, these findings suggest that children often display mild to no symptoms, spotlighting them as an important, transmissive subpopulation of COVID-19.