In order to evaluate the antibody (Ab) response to SARS-CoV-2, Seow et al. took a series of serum samples from 65 health care workers and hospitalized patients who tested positive for COVID-19 up to 94 days post onset of symptoms. The investigators found that the level of neutralizing antibodies (nAb) were dependent on the severity of disease and that nAb levels declined over the follow up period. The results of this study suggest that nAb response to SARS-CoV-2 infection may last only a short period of time, similar to that of nAb responses to coronaviruses associated with common colds.