Multisystem inflammatory syndrome in children (MIS-C) is a rare condition that occurs two to four weeks after children and adolescents experience acute COVID-19. Of 565 patients with MIS-C who were tested for COVID-19, 99.1% received a positive RT-PCR or serology test result. Effects of MIS-C include gastrointestinal symptoms, inflammation, heart complications, and shock. In order to deliver appropriate and timely care, it is crucial to identify and diagnose MIS-C from COVID-19 and other inflammatory diseases.