COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission

August 10, 2020

Pettirosso E, Giles M, Cole S, Rees M.

J Obstet Gynaecol

Was searched the EMBASE and Medline Ovid databases on April 18, May 18 and May 23, 2020, 60 studies were included in the analysis, with 3830 patients in total. The most frequent clinical symptom among pregnant women was fever at admission and postpartum, while 43.5-92% reported asymptomatic infection of SARS-CoV-2 positive patients. In 0-18% of the cohort studies reported pneumonia requiring oxygen support or non-invasive ventilation, 0-5% reported critical disease. Almost all SARS-CoV-2 positive women in these studies who were diagnosed with less than 37 weeks also delivered preterm due to obstetric indication, worsening COVID-19, for no reported indication or a combination of these causes. Nineteen neonates were SARS-CoV-2 positive based on rtPCR of nasopharyngeal swabs, 4 placenta samples and 1 cord blood sample were positive but it wasn´t identified in breastmilk samples. 3 of these were febrile, 15 were asymptomatic and one developed disseminated intravascular coagulopathy, 6 neonates with APGAR < 7, there were no reported deaths of SARS-CoV-2.

Pettirosso E, Giles M, Cole S, Rees M. COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission. Aust N Z J Obstet Gynaecol. 2020 Oct;60(5):640-659. doi: 10.1111/ajo.13204

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