Among children who become ill, manifestations of COVID-19 appear to be similar to those in adults: fever, fatigue, dry cough, and other respiratory symptoms; gastrointestinal manifestations were infrequent. Transmission is likely the same as that seen in adults. Thus far, no convincing evidence of intrauterine transmission has been identified and through breastfeeding is unknown, to our knowledge. If children are infected but asymptomatic, they could serve as a source of transmission to adults. In a study from China, 7 of 20 pediatric patients who were ill with COVID-19 had a prior history of a congenital or acquired disease, leading to suggest the children with underlying illness might be more susceptible. Special accommodations should be made to isolate children who are potentially ill with COVID-19, especially focusing on minimizing exposures for those with special health care needs. Differentiating potential COVID-19 illness from other illnesses, such as influenza, will be difficult until testing for COVID-19 becomes more broadly available. In conclusion, early data suggest that the effects on children are less severe than those on adults, yet many questions remain, especially regarding the effects on children with special health care needs.