This study assessed the clinical and laboratory characteristics of fifty-eight children in England admitted between March 23 and May 16, 2020 presenting with fever and evidence of inflammation, who met the criteria for paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). The authors compared the findings with the clinical presentation of patients with Kawasaki Disease (KD) and KD shock syndrome admitted to European and American hospitals from 2002 to 2019. Of the 58 children,15 were positive by PCR and 40 were positive by IgG antibody test for evidence of SARS-CoV-2 infection. All 58 children presented with fever and nonspecific symptoms, 50% developed shock, 22% met criteria for KD, and 14% had aneurysms or coronary artery dilatation. The findings of this study indicate that PIMS-TS is different from other paediatric inflammatory diseases; however, further research is needed in order develop an optimal treatment for PIMS-TS.