Associations between COVID-19 risk and those with mood disorders, which included individuals with depression or bipolar disorders, were evaluated in this systematic review and meta-analysis. A total of 12 studies with over 91 million individuals were included in this study. Findings revealed that those with mood disorders were more likely to be hospitalized due to COVID-19 illness compared to those who did not have mood disorders (OR=1.31, 95% CI: 1.12-1.53, P= 0.001), and results from the sensitivity analyses showed significance in this association. There was also a significant difference between these two groups when evaluating odds for death due to COVID-19, where those with mood disorders had higher odds of dying from COVID-19 (OR=1.51, 95% CI: 1.34-1.69, P<0.001). When evaluating the relationship between susceptibility to testing positive for COVID-19 or severe events to mood disorders, it was revealed that there was no association between mood disorders and either variable. Results from the sensitivity analyses showed no statistically significant associations. Implications for this systematic review indicated the need for those with mood disorders to be considered at-risk for hospitalization and death due to COVID-19.