Minamikawa et. al. performed a quantitative analysis of 265, 280, and 300 nm wavelength deep ultraviolet light-emitted diode (DUV-LED) on the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To quantify dose, or effective power density, of DUV irradiation, the group fabricated a DUV-LED irradiation apparatus which applied uniform irradiation in a 96-well plate containing virus inoculum. PBS or EMEM containing 2% FBS were selected as the viral culture media to minimize absorptivity. Viral inactivation was evaluated via plaque assay in Vero E6 cells. To achieve 99.9% inactivation of the virus, it was found that a power density of 1.8 mJ/cm2 for 265 nm, 3.0 mJ/cm2 for 280 nm, and 23 mJ/cm2 for 300 nm is necessary—with 265 nm being the most effective. Radical species were produced at all three wavelengths; despite the possibility that these radical species would affect the inactivation of SARS-CoV-2, 300 nm showed the highest level of radical species, indicating radical species are unlikely to affect SARS-CoV-2 inactivation. The group discusses how this work could be improved by future studies investigating the precise mechanism by which viral inactivation occurs via DUV-LED irradiation. * Please note all studies published in medRxiv and bioRxiv are preprints and have not yet undergone a rigorous peer review process.