Deng et al. developed a rhesus macaque model for SARS-CoV-2 infection to evaluate the effects of viral reinfection, or “rechallenge”, after recovery from initial infection, or “initial challenge”. Out of seven monkeys, six were intratracheally infected with SARS-CoV-2, four of which were reinfected 28 days post-initial challenge. The two that were not reinfected served as negative controls during the rechallenge while the one healthy monkey was given an initial challenge during the second challenge as a control. At the same time point after infection, viral loads were lower during reinfection compared to initial infection. Monkeys that were reinfected also demonstrated a greater number of memory lymphocytes and neutralizing antibodies at similar times post-infection, suggesting a protective effect of primary infection. However, the monkeys were reinfected in the early recovery days and additional research is needed to evaluate long-term neutralizing antibody titers for protection against SARS-CoV-2 reinfection.