This retrospective study aimed to understand clinical outcomes of ischemic stroke (IS) patients with COVID-19. Patients from 312 US hospitals with comorbid ischemic stroke and COVID-19 (IS-COVID), between April and July 2020, were identified utilizing the Vizient Clinical Data Base. Results demonstrated that of the 166,586 IS controls with pneumonia and 2,086 IS-COVID patients, IS-COVID patients were more likely to be male, under the age of 75, have diabetes, obesity, and congestive heart failure, and were less likely to have hypertension, dyslipidemia, or be smokers. IS-COVID patients experienced acute complications, such as acute renal failure, acute coronary syndrome, and venous thromboembolism, among others, more often than IS controls. Consistent with previous data, IS-COVID patients were less likely to receive intravenous alteplase injections (1.8% vs. 5.6%) or mechanical thrombectomy (4.4% vs. 6.7%). In-hospital, IS-COVID patients were over four times as likely to die compared to IS controls (30.4% vs. 6.5%) and half as likely to have a favorable discharge (33.9% vs. 66.4%). Demographic data indicated that Black and Hispanic patients, (accounting for 21.7% and 7.4% of IS controls, respectively) disproportionately made up 33.7% and 18.5% of IS-COVID patients.