Ray et al. suggest that the SARS-CoV-2 envelope (E) protein can serve as a vaccine target. Of the three SARS-CoV-2 outer surface proteins, E protein was found to be the most antigenic (with a VaxiJen score of 0.6025) and therefore can yield the greatest immune response. Researchers utilized computational analysis to identify the six best epitopes for future E protein vaccine studies: three B-cell epitopes (VFLLVTLAIL, ILTALRLCAY and LLFLAFVVFL), two major histocompatibility complex class I (MHC-I) T-cell epitopes (LTALRLCAY and VSLVKPSFY), and one MHC class II (MHC-II) T-cell epitope (VFLLVTLAI). These potential epitopes were selected by building a phylogenetic tree with SARS-CoV-2 E protein and related proteins, identifying mutations in the SARS-CoV-2 E protein through comparisons with the consensus E protein of homologous strains, modeling the protein structure and using neural networks on the protein model to predict B-cell and T-cell epitopes. The epitopes generated from this analysis were then tested for antigenicity, hypersensitivity reactions, toxicity, and hydrophilicity to eliminate non-viable antigenic determinants.