A case-control study using a database in Hong Kong was conducted to examine the association of BNT162b2 and CoronaVac vaccination with carditis. A total of 160 case patients and 1533 control participants were included. The incidence of carditis per 100,000 doses of CoronaVac and BNT162b2 administered was estimated to be 0.31 (95% CI, 0.13 to 0.66) and 0.57 (CI, 0.36 to 0.90), respectively. Multivariable analyzes showed that BNT162b2 vaccine recipients had higher odds of carditis (adjusted odds ratio [OR], 3.57 [CI, 1.93 to 6.60]) than unvaccinated individuals. The risk was mainly seen after the second dose of BNT162b2 rather than the first. No association between CoronaVac and carditis was observed with a magnitude similar to that of BNT162b2.