This report highlights the need for additional primary care involvement in the COVID-19 response to improve patient outcomes, especially in the context of recent case increases. Data suggests that 30% of registered COVID-19 deaths occurred outside hospitals, reinforcing a need for care at home and in outpatient health services. Primary care is faced with new challenges as they must provide care for initial COVID-19 cases and the accumulation of other diseases. Therefore, the UK general practice is implementing new models of care to help patients with complex health. The GPs must be a part of a strategy that prepares the NHS for COVID-19 outbreaks, deferring management of other conditions and simultaneous epidemics. Communication and integration of primary care providers with public health and secondary care decision-makers is critical. Primary care allows for early interventions to reduce the risk of adverse outcomes, enhance system resilience in response to health challenges arising from COVID-19, and continuity of care. Therefore, greater investment in primary care research and stakeholders is urgent to improve the care of vulnerable patients.