Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

January 25, 2022

Oster et al., 2022

JAMA Cardiology

In this descriptive study of reports of myocarditis to the Vaccine Adverse Event Reporting System (VAERS) that occurred after administration of the mRNA-based COVID-19 vaccine between December 2020 and August 2021. Men comprised 82% Of the cases, the median age was 21 years and the median time to symptom onset was 2 days. There were 826 cases of myocarditis among those under 30 years of age; of these cases, 98% had elevated troponin levels, 72% had abnormal EKG results, and 72% had abnormal cardiac MRI results. 96% of people were hospitalized. Based on surveillance reports in the US, the risk of myocarditis after receiving mRNA-based COVID-19 vaccines increased after the second vaccination dose in adolescent and young men. This risk should be considered in the context of vaccination against COVID-19.

Oster ME, Shay DK, Su JR, et al. Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021. JAMA 2022; 327: 331.

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