Adverse events of special interest following the use of BNT162b2 in adolescents: a population-based retrospective cohort study
January 28, 2022
Lai; Chua; Chan; et al.
Emerging Microbes & Infections
Two retrospective cohorts were formed in a Hong Kong population-wide database to observe 28 days after the first and second doses of BNT162b2. Thirty adverse effects associated with vaccination were examined. The first dose cohort comprised 274,881 adolescents (50.25% received the first dose) and the second dose cohort 237,964 (50.29% received the second dose). 94 adolescents in the first dose cohort and 130 in the second dose cohort experienced ≥1 adverse event. There was no significant difference in the risk of any adverse effect associated with BNT162b2 except myocarditis [first-dose cohort: incidence rate (IRR) = 9.15, 95% confidence interval (CI) 1.14–73, 16; second dose cohort: IRR = 29.61, 95% CI 4.04–217.07] and sleep disturbances after second dose (IRR = 2.06, 95% CI 1.01–4.24 ).
Lai FTT, Chua GT, Chan EWW, et al. Adverse events of special interest following the use of BNT162b2 in adolescents: a population-based retrospective cohort study. Emerging Microbes & Infections 2022; 11: 885–93.